Teflaro, Zinforo(ceftaroline fosamil)
Teflaro, Zinforo (ceftaroline fosamil) is a small molecule pharmaceutical. Ceftaroline fosamil was first approved as Teflaro on 2010-10-29. It is used to treat escherichia coli infections, infectious skin diseases, klebsiella infections, pneumonia, and staphylococcal infections amongst others in the USA. It has been approved in Europe to treat community-acquired infections, infectious skin diseases, and pneumonia.
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54 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | 2 | 2 | 5 | — | 8 |
| Pneumonia | D011014 | EFO_0003106 | — | 1 | 1 | 2 | 2 | 2 | 7 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | — | 3 | 1 | — | 4 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | — | 3 | 1 | 4 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | 1 | — | 1 | — | 2 |
| Endocarditis | D004696 | HP_0100584 | — | — | — | — | 2 | — | 2 |
| Community-acquired infections | D017714 | — | — | — | — | 1 | 1 | — | 2 |
| Critical illness | D016638 | — | — | — | — | — | 1 | — | 1 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | — | — | 1 | — | 1 |
| Open fractures | D005597 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial infections | D001424 | — | A49 | — | 1 | 2 | — | 1 | 4 |
| Soft tissue infections | D018461 | — | — | — | — | 2 | — | 1 | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | — | — | — | 1 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Meningitis | D008581 | HP_0001287 | G03 | 1 | — | — | — | — | 1 |
| Cerebrospinal fluid shunts | D002557 | — | — | 1 | — | — | — | — | 1 |
| Ventriculoperitoneal shunt | D017287 | — | — | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | 1 | — | — | — | — | 1 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | 1 | — | — | — | — | 1 |
| Aids-related complex | D000386 | EFO_0007137 | B20 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mycoses | D009181 | — | B35-B49 | — | — | — | — | 1 | 1 |
| Inappropriate prescribing | D057970 | — | — | — | — | — | — | 1 | 1 |
| Bacterial skin diseases | D017192 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ceftaroline fosamil |
| INN | ceftaroline fosamil |
| Description | Ceftaroline fosamil acetate monohydrate is a hydrate that is the monohydrate form of ceftaroline fosamil acetate. A prodrug for ceftaroline, used for the treatment of adults with acute bacterial skin and skin structure infections. It has a role as an antimicrobial agent, an antibacterial drug and a prodrug. It contains a ceftaroline fosamil acetate. |
| Classification | Small molecule |
| Drug class | cephalosporins; phosphoro-derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n1 |
Identifiers
| PDB | — |
| CAS-ID | 229016-73-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL501122 |
| ChEBI ID | 70718 |
| PubChem CID | 16007393 |
| DrugBank | DB06590 |
| UNII ID | 7P6FQA5D21 (ChemIDplus, GSRS) |
Target
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Teflaro – Allergan
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Teflaro – Warner Chilcott
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Safety
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679 adverse events reported
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