Teflaro, Zinforo(ceftaroline fosamil)
Teflaro, Zinforo (ceftaroline fosamil) is a small molecule pharmaceutical. Ceftaroline fosamil was first approved as Teflaro on 2010-10-29. It is used to treat escherichia coli infections, infectious skin diseases, klebsiella infections, pneumonia, and staphylococcal infections amongst others in the USA. It has been approved in Europe to treat community-acquired infections, infectious skin diseases, and pneumonia.
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Commercial
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Clinical Trials
55 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Soft tissue infections | D018461 | — | — | — | — | 2 | — | 1 | 3 |
| Bacterial infections | D001424 | — | A49 | — | — | 2 | — | — | 2 |
| Infectious skin diseases | D012874 | — | — | — | — | 2 | — | — | 2 |
| Wound infection | D014946 | — | — | — | — | 2 | — | — | 2 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | — | 2 | — | — | 2 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | 1 | — | 1 | 2 |
| Community-acquired infections | D017714 | — | — | — | — | 1 | — | — | 1 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | — | 1 | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
| Retinal diseases | D012164 | — | H35.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Communicable diseases | D003141 | — | — | — | — | — | — | 1 | 1 |
| Community-acquired pneumonia | D000098968 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ceftaroline fosamil |
| INN | ceftaroline fosamil |
| Description | Ceftaroline fosamil acetate monohydrate is a hydrate that is the monohydrate form of ceftaroline fosamil acetate. A prodrug for ceftaroline, used for the treatment of adults with acute bacterial skin and skin structure infections. It has a role as an antimicrobial agent, an antibacterial drug and a prodrug. It contains a ceftaroline fosamil acetate. |
| Classification | Small molecule |
| Drug class | cephalosporins; phosphoro-derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n1 |
Identifiers
| PDB | — |
| CAS-ID | 229016-73-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL501122 |
| ChEBI ID | 70718 |
| PubChem CID | 16007393 |
| DrugBank | DB06590 |
| UNII ID | 7P6FQA5D21 (ChemIDplus, GSRS) |
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Teflaro – Allergan
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Teflaro – Warner Chilcott
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Safety
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900 adverse events reported
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